A Simple Alternative to Antihistamines

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Revised on December 8th, 2022

Does your favorite rose bush leave you sneezing, or a bug bite cause an itchy welt on your arm? Chances are you’ve popped a little pink antihistamine pill looking for help. Antihistamines block the body’s histamine receptors. Histamine is a substance released by cells when something harmful is detected like an allergen such as a flower’s pollen or the sting of an insect. These drugs provide some relief, but your symptoms will come roaring back once they’ve worn off. They also come with that one big drawback you know all too well — excessive sleepiness — because they inhibit other essential functions that histamine has in your body.

Fortunately, homeopathy has a simple answer for those suffering from allergies. Histaminum hydrochloricum is a versatile remedy that works for a range of allergic conditions.

How Histamine Works

Histamine is present in the cells and tissues throughout your body, and it’s also naturally occurring in the venom of wasps, bees, and jellyfish. People with allergies may view histamine as the enemy, but it serves a necessary purpose.

On a basic level, histamine helps protect the body and get rid of things that bother you. For instance, histamine gets released during injuries and infections. It works to increase blood flow in the affected area for the benefit of healing. It’s this blood flow effect (vasodilation) that unfortunately causes you to itch, sneeze, or tear up in response to an allergen, which your body perceives as a threat and attacks. As a neurotransmitter, histamine also sends signals to your stomach to produce acid and to your brain to keep you alert, which is the reason antihistamines can leave you feeling sluggish.

Issues arise when histamine levels are excessive, as is the case with allergic conditions. In these situations, harmless substances like food or pollen can set off rapid production of more histamine. As you continue to encounter these triggers, histamine production stays high and leads to those well-known and annoying reactions in our eyes, nose, and skin.

Histaminum Hydrochloricum for Allergies

Histaminum hydrochloricum is prepared from a salt of histamine called histamine dihydrochloride. Unlike antihistamines that block the body’s response, a microdose of histamine dihydrochloride can stimulate your body's healing response to bring it back into balance. You’ll get all the benefits of allergy relief without feeling drowsy.

This “blue tube” medicine is so versatile that you’ll want to keep it always stocked in your first aid kit. It relieves symptoms of allergic conditions, including hay fever.* You can find it as an active ingredient in AllergyCalm for this purpose. It’s also a useful remedy for hives and reactions to insect stings.*

For general use throughout allergy season, dissolve 5 pellets of Histaminum hydrochloricum 30C under the tongue three times a day until symptoms are relieved. When treating hives and other skin reactions, use 5 pellets every hour, then decrease the frequency as your symptoms improve.

Want to learn more about the homeopathic uses of Boiron Histaminum hydrochloricum? Watch this video featuring pharmacist Gary Kracoff, NMD, R.Ph.

*Claims based on traditional homeopathic practice, not accepted medical evidence. Not FDA evaluated.

Just for our blog readers! Get 10% off this medicine with coupon code BLOG when you enter at checkout.

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Comments (62)

Linda Brownsays:

Hello, My husband is in ICU right now but not on a ventilator,, but on high flow oxygen.. The Dr. is saying he doesn’t have a lot of mucous but has inflammation.. Would Histamine 30 CH help him in any way..


Hello Linda, so very sorry about your husband and we wish him a speedy recovery. Homeopathic treatments for chronic conditions are very specific to each patient. There may be a homeopathic treatment that addresses your condition, but we recommend consulting a practitioner knowledgeable in homeopathy. You can contact the National Center for Homeopathy at (856) 437-4752 or visit to find one in your area.

Annie Oceansays:

I am having a rash spreading over my body from exposure to two covid vaccinated people..
what homeopathy could I use for this?


Thanks for your question, Annie. At this point, not much is known about the effect of the COVID-19 vaccine on homeopathic medications and vice versa. For information about specific drugs, check with your health care provider.

Maria fiskesays:

I have narrow angle glaucoma , and I want to know if this is safe to take it …. I have always take them and I love them …… I know I can’t take over the counter ,regular Medicine for allergies …. This is my only hope


Hello Maria, yes it is safe to take. Histaminum doesn’t contain decongestants or conventional antihistamines, which, in allopathic medications, are responsible for the interference with glaucoma. Additionally, Histaminum has no known interactions with other medications.


I’m allergic to antihistamines. It causes me to itch but mostly I cough. Would this help?


Sorry. I forgot to say would this medicine help for those who are allergic to antihistamine.


Hello Cheryl, yes, Histaminum works with your body to relieve allergy symptoms brought on by the overproduction of histamine. It doesn’t mask or suppress, so it makes a great alternative to conventional antihistamines that only work by blocking histamine.

Emily Hsays:

Hello! I am looking for a homeopathic option for an antihistamine that will clear up postnasal drip/congestion. I am currently breast-feeding. I purchased Histaminum Hydrochloricum – is this the correct one for what I am trying to accomplish? And is this breast-feeding safe? Thanks so much!


Hi Emily, Histaminum is a great first choice for allergy relief and there is also Hydrastis canadensis if postnasal drip is your main symptom. You can take both together during an allergy flare-up if needed; however if pregnant or breastfeeding, please ask your health care professional before taking any medicine, including Boiron homeopathic medicines. If your health care professional needs more information on our medicines, they can contact us at 1-800-BOIRON-1.

Rakesh Dadlanisays:

I started taking boiron histamine hydrochlorium 30 c three pellets under the tongue for nasal allergy it has a lot of side effects like cold sweat, drowsiness, excessive sleep all daywith n throat dry mouth and gets your body temperature down even if you don’t have fever. But the medicine says a different story that it has no side effects. So I stopped it immediately.


Hi Rakesh, can you please give us a call at 1-800-BOIRON-1 so we can learn more about what happened? Thank you.


My daughter just had a hives reaction to the pellets.


Hi Chloe, can you please give us a call at 1-800-264-7661? We would like to learn more about what happened and gather more information, thank you.


Hi which homeo medicine is good for GERD , regurgitation. Thank You


Hi Sneha, GERD is a digestive disorder that requires diagnosis by a professional. But for occasional bouts of heartburn and acid indigestion, check out Boiron Acidil.


Our older teenager has allergies and a hand eczema breakout including blisters and red spots. Is it safe to take Histaminum hydrochloricum 30c and Sulfur 200ck together?


Thank you for your question, David. Yes, it is safe to take more than one homeopathic medicine at the same time. They can be taken together and there’s no need to stagger or alternate the doses.


I was recently stung by a yellow jacket wasp, and a few days later have a about a 2 inch rash that itches. Is Histaminum Hydrochloricum what I need to take? And is it safe to take during pregnancy?


Hi Keri, Histaminum relieves symptoms of allergies, including reactions from insect stings. You can try that on its own or take it alongside Urtica urens if needed for additional relief from skin rashes with itching due to allergies. If you are pregnant or breastfeeding, we recommend you speak to your health care professional before taking any medication, including Boiron medicines. Thank you!


Hi, I’m 12 weeks pregnant and i have terrible allergies this year. Hay fever, watery eyes…the works. Can i take this?


Hello JJ, it’s best to talk with your medical provider before taking any medications, including Boiron homeopathic medicines, while pregnant or breastfeeding.


I’ve been using Afrin to open nasal passages in order to breathe due to allergies and sinus issues. I want a more natural remedy for these issues. What pellet recommendations can you suggest to relieve my continuous nasal congestion.


Hello Eldon, we recommend our SinusCalm tablets for nasal congestion, pain, and stuffy nose from allergies. If you’re looking for more individualized treatment, then please check out the free Boiron Medicine Finder to browse symptoms and recommended medicines.


Does Histaminum hydrochloricum work for a stress induced histamine intolerance? It is not allergy, but a condition of Mast Cells Activation Syndrome.
Does it work in people who have histamine overproduction due to exposure to different factors?


Hi Eve, because of the nature of your condition, it would be best to speak to a practitioner knowledgeable in homeopathy about your treatment. Histaminum or other homeopathic medicines may be beneficial and they would be able to develop a medicine regimen just for you. Contact the National Center for Homeopathy at or to find one in your area.


Good day! Can I take sinusalia and hydrarastis canadensis together?


Hi Mika, yes, you can safely take Sinusalia and Hydrastis at the same time. Homeopathic medicines have no known interactions with other medicines, herbs, or supplements as well.

Karen Newmansays:

Hi I was wondering whether Oscillococinum would negate the effect of the Covid or Flu vaccine? I experienced prolonged effects from the first two vaccines like fatigue, nausea, headaches…. and for the first two days, flu like symptoms. I found that Arnica and Hypericum helped with the body aches with the first two vaccines. The side effects from the second jab was worse than the first. I’m due to get the Booster jab next week and thought I might try to alleviate the side effects. Thanks


Thank you for your question, Karen. At this point, not much is known about the effect of the COVID-19 vaccine on medications and vice versa. For information about specific drug use and the vaccine, check with your health care provider.


Hi boiron. I am suffering from allergic rhinitis in winter season from 13 years.i have tried so many medicines.but no permanent treatment is has runy nose, nasal blocked,sunizing,itching symtoms.
Can you suggest me medicines.
So it can be treated.


Hi Ravi, our RhinAllergy Tablets sound like a good fit for you. They address a variety of allergy symptoms, including itchy, watery, burning and irritated eyes; sneezing; runny nose; and itchy throat and nose.


Hi I have itchy throat and cough and it’s getting worse because of the cold season I guess does Boiron Histaminum Hydrochloricum will work ?


Hello Kabita, yes Histaminum can help. Also consider checking out our RhinAllergy Tablets . This contains Histaminum as well as other homeopathic medicines that can help with spasmodic coughing associated with hay fever.


Hi, my 17 year old had been coming up with Urticaria type skin rash for last 4-5 months. Have ruled out food groups but still cannot really figure out what the problem is. He has been taking antihistamines and steroidal creams to releive the itchiness.
Will Histaminum help?
Could this sudden occurrence of urticaria be because of hormones at this age. Has anyone had this experience with their teenagers?


Hi Vandy, if the rash is caused by an allergy, then Histaminum is indicated. Urtica urens is another popular remedy for allergic skin reactions. However, these medicines are only for over-the-counter use for up to three days. If you wish to use them for longer, we recommend reaching out to a homeopathic practitioner who can prescribe a treatment regimen tailored to your teen. Find one in your area by contacting the National Center for Homeopathy at or visit


Yes, my first time breaking out with random hives I was 16 and I am now 44 and still have them. They come when my body gets too hot. I was told by a doctor the nerves can be triggered by a crises in your life. At the time that made since. Why I still suffer from them I don’t know. I have no food allergies or anything. It’s horrible they break out and itch so bad. I’ve been on Claritin and Zyrtec for years to keep it away. It helps, but I’m afraid I am having side effects of those meds now that I’ve been on them so long. That’s why I’m looking into this now.


Hi, I am 62 years and have Synovitis of the knee. What homeopathic medicine(s) would you recommend? Thanks


Hello Nishi, Rhus tox and Bryonia are two main homeopathic medicines for joint pain. Use Rhus tox if moving helps improve your knee pain, or choose Bryonia if your knee is better when rested. You will find both medicines in our Arnicare Arthritis formula, which is easy to use and address multiple symptoms of joint pain.


Dear all,
I have tried Histaminum 30ch and 200ch for trying to get relieve for the moments where my histamine levels are over the expected and, due to my *histamine intolerance* ground, affects to my sleeping a lot.
I know that “every patient a different treatment” BUT, is there a way to counteract or nullify the histamine levels in blood given that Histaminum 30ch or 200ch does not give relief in my case ? (only affects to sleep)
thanks! 😉


Hi Pedro, it would be best to speak to a practitioner knowledgeable in homeopathy about your condition. They will work to get to the root cause of your intolerance and can recommend which medicines and in which dosages will help you the most. To find one in your area, please visit the National Center for Homeopathy. There is a tool to help you locate a homeopath under the Resources section.


Can I safely take Histaminum pellets for allergies if I am currently taking blood pressure medicine?


Hi Delane, yes you can safety take Histaminum pellets alongside other medications including those for blood pressure. There are no known interactions between homeopathic medicines and other drugs, supplements, or herbs.


Redness in face and almost a sunburn feeling- can this be a side effect after taking the Histaminum pellets?


Hello Vicki, please contact the Boiron Information Center at or call us at 1-800-264-7661 so we can learn more about your situation.


Have you ever had anyone with Mast Cell Activation Syndrome use histaminum?


Hello Jenna, as a manufacturer, we offer over-the-counter medicines for acute, self-limiting conditions. However, health care professionals may instruct their patients to use the medicine for other conditions. Homeopathic treatments for chronic conditions like Mast Cell Activation Syndrome are very specific to each patient. There may be a homeopathic treatment that addresses your condition, but we recommend consulting a practitioner knowledgeable in homeopathy. If you do not have a practitioner, please contact the National Center for Homeopathy at or visit


I take Singular and want to stop. I have tree and grass pollen allergies., but I am also lethargic all summer into fall. Can you recommend something? I use Arnica for arthritis and like it a lot. Allergy season is starting and I need help. Thank you


Hi Linda, we recommend non-drowsy RhinAllergy medicine. It relieves symptoms of hay fever and other respiratory allergies, including itchy and watery eyes, runny nose, and spasmodic coughing in easy-to-use meltaway tablets, no water needed. Singular is a prescription medication, so please speak to your doctor before stopping it. RhinAllergy has no known drug interactions, so it’s safe to take with Singular or other medications you may already be using.

Richard Pickeringsays:

Please explain what the various dilution levels are and their significance. Thanks


Hi Richard, homeopathic medicines are available in various dilutions, but C, X, and CK are the most common. The letter indicates which dilution process was chosen, while the number indicates how many times that dilution process was used, and consequently, which symptoms the medicine is meant to treat. You can read more about that here on this page.

Low dilutions, such as 6X or 6C, will relieve local symptoms such as those can point a finger at (e.g., an insect bite or bruise). High dilutions, such as 30X or 30C, will relieve general symptoms, which is more than one symptom in more than one location with possible behavioral or emotional symptoms (e.g., a very high fever and chills, accompanied by agitation or sleeplessness). If a person has the right medicine, no matter what the dilution, he will see a lessening of symptoms.

Bidisha chaudhurisays:

Does histamin hydro..cure permanently the allergy symptoms like hey fever,rhinitis ,allergy cough etc?plz help me..


Hi Bidisha, Histaminum provides temporary relief of allergy symptoms. It is not a permanent cure. Call us at 1-800-BOIRON-1 if you have any more questions, thanks.


I have horrible congestion and have been trying to make sure that the Histaminum Hydrochloricum or sinucalm won’t raise my blood pressure, I am on blood pressure medication and know they can be taken together but will it raise blood pressure ? Thank you


Hi Courtney, homeopathic medicines will not raise your blood pressure or interact with blood pressure medication. SinusCalm and Histaminum do not contain conventional decongestants (like phenylephrine), which are the ingredients responsible for increasing blood pressure and heart rate in allopathic over-the-counter sinus and allergy medicines.


I may have mast cell activation syndrome blood test shows allergies of ragweed, pollen, cedar, dust mites.. Will Histaminum hydrochloricum help
Homeopathic practitioners are so expensive in my area..
Can you help/suggest what can I take for these..


Hi Puja, Histaminum relieves symptoms of all allergic conditions, including indoor/outdoor and seasonal allergies, as well as hives. However, we do recommend consulting a homeopathic practitioner who can provide you with an individualized treatment plan.


Is it safe with ckd?


Hi Tim, Histaminum is not contraindicated with your condition, but be sure to consult with your healthcare provider regarding OTC medications including homeopathics. Thanks!


Hi, I am taking metphormin, zenuvia for diabetes, also taking weekly pen injection Trulicity for diabetes. I am taking Singulair for bronchitis, Astrovastatin for cholesterol, Remipril for blood pressure, potassium citrate for kidney. I recently have hives, I bought Histaminum hydrochlorocium 30c, is it okay for me to take it? Please let me know.


Hi hj, there are no known interactions between Histaminum 30C and the medications you listed. In general, homeopathic medicines above 4C and 8X have no risk of interfering with other drugs, herbs, or supplements. You can always call us at 1-800-BOIRON-1 if have any questions, thanks.

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